From mean tweets to a retrospective of his life, Jennifer Aniston, Kim Kardashian and George Clooney among stars serving up surprise after surprise.
In a special segment called "Mean Tweets: Jimmy Kimmel Edition," longtime friend Ray Romano summoned the blow, calling Michael Keaton, Halle Berry, Anthony Anderson, Howard Stern, David Spade, Chris Hemsworth, Kristen Bell, Jon Stewart, Tracy Morgan, Amy Schumer, Liam Neeson, Larry David, Mike Tyson, Jeff Bridges, Zach Galifianakis, Stephen Colbert, Jennifer Lawrence, David Letterman and Will Ferrell to read some of Kimmel's fans' harshest insults.
Some of the funniest tweets included, "Is Jimmy Kimmel cross-eyed or just ridiculously ugly?" and "Your job is to pollute the airwaves with your worthless bullshit. F-ck off, you big giant turd."
But Kim Kardashian read perhaps the most savage of tweets from her husband, Kanye West, who wrote, "JIMMY KIMMEL PUT YOURSELF IN MY SHOES ... OH NO THAT MEANS YOU WOULD HAVE GOTTEN TOO MUCH GOOD PUSSY IN YOUR LIFE."
Ben Affleck and director J.J. Abrams also stopped by Monday's show to bring to life a comic book Kimmel created as a child -- "The Terrific Ten" -- in a major motion picture starring Affleck, Galifianakis, Matt Damon, Jennifer Aniston, Jason Bateman, Will Arnett, Cousin Sal, Jon Hamm, Shaquille O'Neal, Ty Burrell, Billy Crudup, Jake Tapper and Wanda Sykes.
"That is a comic book I drew when I was about 9 years old, 10 years old," Kimmel explained to Abrams, who had brought the original copy with him. "That's Muscle Man and Color Kid -- those are the main heroes. This is ridiculous. That's Lucky Lad, who's like a leprechaun... Color Kid was the best, though, because he had all the powers of the rainbow, which are really none."
But perhaps the most special surprise of the night was a retrospective of Kimmel's life, put together by George Clooney.
"Hello, I'm George Clooney," the two-time Oscar winner began. "Join us now for the next four-and-a-half hours as we take a look behind the beard at Jimmy Kimmel: 50, fierce and fabulous."
Don't worry -- the four-and-a-half hours is actually closer to four-and-a-half minutes, which we've included below for your convenience.
Happy birthday, Jimmy!