"Please never ask me why I left the film/TV business," the "Breakfast Club" star tweets.
Although the actress, who is best known for playing Allison Reynolds in "The Breakfast Club," also called out Globes nominee Christian Slater, although she didn't make or allude to any specific allegations against either men.
"James Franco just won. Please never ask me why I left the film/Tv business," she tweeted after the actor won the Best Performance by an Actor in a Motion Picture - Musical or Comedy category. "OK wait. Bye. Christian Slater and James Franco at table on Golden Globes #MeToo."
"Why is a man hosting? Why is James Franco allowed in? Said too much. Nite, love ya Golden Globes," Sheedy added.
Sheedy and Franco worked together in his off-Broadway theater directorial debut, "The Long Shrift," in 2014.
Franco made headlines in 2014 after he sent flirty private Instagram messages to a teenager.
During an appearance with "Live with Kelly and Michael," Franco admitted that he did participate in the conversation with a 17-year-old young woman while he was 35.
"I guess I'm, you know, embarrassed, and I guess I'm just a model of how social media is tricky," he said.
Actresses protested this year's awards by wearing black in solidarity with the #MeToo movement which was dedicated to eradicating harassment and gender inequality across all industries in America.