The media icon also reveals what she learned at Prince Harry and Meghan Markle's royal wedding.
Her acceptance speech -- in which she said, "a new day is on the horizon" -- left people speculating (and hoping) she would run for office, but the media icon says she simply couldn't stomach working in such a "bullshit" field.
"In that political structure -- all the non-truths, the bullshit, the crap, the nastiness, the backhanded backroom stuff that goes on -- I feel like I could not exist," Oprah told British Vogue. "I would not be able to do it. It's not a clean business. It would kill me."
Oprah, who graces the cover of British Vogue's August issue, also spoke about the #MeToo and #TimesUp movements, which the television personality says she sees as a shift in the right direction.
"People talk about 'these are such dark times,' but what if we shift the paradigm? Because I see it differently," she said. "I see, 'Isn't this remarkable that we're waking up?' For years, women have endured craziness. This is what's happening to people. They're allowing themselves to not just become corroded, but to become hysterical. You've got to lean to the happiness."
"It left me feeling that anything is possible through the power of love," she said. "Reverend Curry was right!"
Oprah's full interview will appear in the August issue of British Vogue, which hits newsstands July 6.