In August, the former "Blossom" star was involved in a car accident in Los Angeles which left her with a "brutal" injury to her left hand, some reports even saying she was close to losing fingers.
Thankfully that didn't happen and she's still healing, but now comes more bad news -- the Emmy nominee for "The Big Bang Theory" just took to her parenting blog to announce that she is divorcing her husband of nine years, Michael Stone.
"After much consideration and soul-searching, Michael and I have arrived at the decision to divorce due to 'Irreconcilable Differences,'" Mayim's statement begins.
"Divorce is terribly sad, painful and incomprehensible for children. It is not something we have decided lightly.
The hands-on style of parenting we practice played no role in the changes that led to this decision; relationships are complicated no matter what style of parenting you choose.
The main priority for us now is to make the transition to two loving homes as smooth and painless as possible. Our sons deserve parents committed to their growth and health and that's what we are focusing on. Our privacy has always been important and is even more so now, and we thank you in advance for respecting it as we negotiate this new terrain.
We will be ok."
The couple has two sons -- Miles, 7, and Frederick, 4 -- and Mayim has been an outspoken advocate of attachment parenting, which includes breastfeeding for several years and allowing children to sleep in bed with their parents. As recently as May, the actress confessed that she was still breastfeeding her then 3-year-old.
Click "Launch Gallery" above to see the most shocking celeb splits over the years.