And last night on "Conan," she struck gold once again.
A conversation about her nymphomaniac character's jewelry in the film took a left turn on Thursday, as Aniston revealed she was actually wearing a sex toy around her neck the entire flick.
We can't type it here, so watch the video above to see what it was -- and Conan's speechless reaction to her dirty mouth.
"We're just saying all sorts of s**t on this show," she joked. O'Brien's response: "Don't worry about it, this airs very late on Nickelodeon!"
It got a little uncomfortable a little later on though, as Jen talked about a "sex scene" that was cut from the final film -- one where Aniston says her character "exploits" Charlie Day's character while he's "in a coma."
Yeah, we can see why what actually sounds like a rape scene (and not a funny, consensual sex montage) would be cut ... though Jen says she bets it'll be on the "DVD extras."