The "Friends" alum got emotional while speaking at the 46th Annual Giffoni Film Festival in Italy over the weekend, when a young jury member asked if the actress has ever questioned who she was.
"Yes, that moment has happened to me," she told the audience, visibly emotional. "There's not enough fingers and toes in this entire room to count how many times that moment has happened."
"We're all human beings at the end of the day, whether we're a waitress or we're a baker or we're a student – whatever we are, at the end of the day, you can kind of hit walls and think 'I can't go any farther' or 'This is too much, my heart can't take it' or 'The pain is too great' or 'Am I good enough?' or, 'Will I survive?' " she continued. "And you just have to sort of, somehow, miraculously overcome. You just go, 'I can.' Yes, you can."
The 47-year-old "Cake" actress was honored at the festival for the Lifetime Achievement Award. During the ceremony, Aniston also opened up about life as a working actress.
"Also know that your actors, your idols, your icons – whatever you call them – have all had that experience or that moment in their lives, many many times," she explained.
"There's nothing that separates us from you because we all started at the same place," she added. "We all came out of nowhere... don't punish yourself, if you feel that."
It's great to see the softer side of Jen -- what do you think about her candid comments? Sound off below and check out the gallery above to see more leading ladies then and now!