She also dings President Trump while talking about her disdain for Twitter.
The media mogul and television personality told InStyle Magazine she's not interested in becoming the next president of the United States of America.
"I've always felt very secure and confident with myself in knowing what I could do and what I could not and so it's not something that interest me," she said. "I don't have the DNA for it."
That might come as a bummer to all those rallying behind the #Oprah2020 hashtag on Twitter after her inspiring Golden Globes speech, which was enough to get Meryl Streep on board to write her hypothetical campaign check, while Steven Spielberg also said he'd support Winfrey if she ran.
If you're wondering by Winfrey didn't address the rampant speculation on Twitter, it's because she's not a fan of the platform, unlike our current president, Donald Trump.
"I try not to lean into the hysteria," she said. "I've heard a lot of Twitter chatter when people have said, 'Where are you? You should be speaking up on these things.' But it makes no sense to speak when you cannot be heard. One hundred and forty characters -- that is not how you want to make your mark in the world."
And Winfrey feels like her way of making a mark at the moment is by giving voices to those who have been silenced for so long.
"Everything that's happened has brought us to this point in time. We've been working our way through a lot of repressed pain, anger, shame and disappointment," she said. "And we weren't honoring our own voices. Now we're here and it took Harvey Weinstein to burst that door wide open. But Harvey wasn't the first one. It was Bill Cosby before him, and Bill O'Reilly before him. It's just fascinating to me because I always try to look at things from thousands of feet above."
Winfrey concluded hoping that women all over the world will be inspired by the numerous actresses who have stepped forward with their own personal stories of sexual harassment, abuse and even rape in the workplace.
"It has seared into the consciousness -- a level of awareness -- that was not there before. That's the most important thing to me," she said. "When Reese Witherspoon can tell her story at the same time as a farm worker in Iowa or a factory worker in Alabama, it says to a person, 'Oh well, I've been putting up with that asshole supervisor for all these years. Maybe it's time for me to do something too."