His comment was in response to Ben Domenech from The Federalist comparing the gun control debate to a 1997 episode of the Fox series where Lisa says the Second Amendment "is a remnant from revolutionary days — it has no meaning today."
Shortly after the Texas Senator's remarks started to circulate through Twitter, the cartoon's showrunner Al Jean expressed his disapproval and made it clear Maggie wouldn't vote Republican.
"Ted Cruz says Maggie Simpson would vote for him. I think Ted's the one who could use a pacifier in his mouth," Jean tweeted. "The way things are going, even Mr. Burns is thinking of becoming a Democrat," he added.
The series is infamous for its predictions and even guessed in 2000 that Donald Trump would someday become president, before being succeeded by Lisa Simpson. This point was mentioned in quite a few of the tweets that went viral after Cruz's comments.
"Bart is named as an anagram for brat. Homer is a complete idiot. Maggie is a baby. Lisa becomes president as an adult and is actually Donald Trump's successor. I don't know who fed Ted Cruz that line, but they obviously don't watch 'The Simpsons,'" sports writer Brian Murphy said.
"My new conspiracy theory, which I believe with all my heart, is that Ted Cruz has never seen 'The Simpsons' and a staffer just read the Wikipedia page to him," New Republic reporter Sarah Jones added.
Keep reading to see how Twitter laughed and rolled its virtual eyes at the Texas senator.
The NRA hijacking Leslie Knope. Ted Cruz trying to co-opt The Simpsons. These are symptoms of the GOP panicking 'cuz smart teens are owning them left and right, but not knowing how to reach said teens. Next up: Rubio raps!
The entire point of the Simpsons is that Homer is a walking example of what not to do and Lisa is the voice of reason. Ted Cruz is the least self-aware organism on the planet. pic.twitter.com/giiuUz8sOK
Does... does Ted Cruz know that the long-running gag is that Lisa is the only smart Simpson and everyone else is a biting parody of stupid, boorish Americans? There was even a whole episode about that - Lisa The Simpson.
ted cruz was 19 when the simpsons debuted and in his early to mid twenties when the show was at its peak, MY MAN, how are you still confused about which of the family members is supposed to be the straight man
The Simpsons are social satire & Lisa represents the intelligent, rational few who are regularly drowned out in society by the loud & boorish Homers of the world. Idk if Ted meant it to be accurate in that way, tho https://t.co/7yFKLbgxz2