"You can not just say to somebody I was sexually assaulted," she argued. "Because sometimes the media goes so far and they way they portray some stories, it's not correct. It's not right."
The interview takes place overseas, following President Donald Trump's wife on a tour of four African countries. She sat down in Kenya to answer questions, and according to the ABC reporter, no subject was off limits.
"I support the women and they need to be heard. We need to support them, and also men, not just women," she said. "You need to have really hard evidence that if you [accuse someone], show the evidence."
WATCH: One-on-one with First Lady @MelaniaTrump. She's opening up for the first time about her life and her time in the White House to @TomLlamasABC.
Her comments on the hot topic come after President Trump's Supreme Court nominee Brett Kavanaugh was confirmed by the Senate, despite psychologist Dr. Christine Blasey Ford coming forward with a sexual assault allegation against the judge.
Trump initially called her story "credible," then proceeded to mock her at his rallies. More recently, he called Dr. Ford's allegation "a hoax that was set up by the Democrats."
"It was all made up, it was fabricated, and it's a disgrace," he told reporters on Monday.
Of course, Trump himself has been accused of varying degrees of sexual assault, misconduct and harassment. According to Business Insider, 22 women have spoken out against the president of the United States. He has always denied any allegation of improper behavior.
On the campaign trail before the 2016 presidential election, audio of Trump talking about grabbing women "by the pussy" emerged. He apologized for the offensive language, but explained it was just "locker room talk."