The pair's on-screen chemistry clearly comes naturally as their banter throughout Cohen's show was an absolute delight to watch. Even more adorable, they kept randomly holding one another's hands as they talked about the film and their friendship.
But like all friends, it isn't always sunshine and roses, as when Cohen asked them to identify who was better at certain things and they gave very different responses when he brought up cooking.
It proved just the tip of the iceberg in a free-ranging interview that tackled if Lopez will ever perform at the Super Bowl, how Remini's former Scientologist friends literally run away from her now, who's gotten more action on a film set and plenty more.
While the only real conflict Remini seems to have with Lopez is her own cooking, it's a different story with many of her former friends over the years. Things changed dramatically for the actress after she not only stepped away from Scientology, but began to speak out against the organization and its teachings.
Cohen brought up Remini's strained relationship with those who are still Scientologists by asking if it surprised her when "The Handmaid's Tale" star Elisabeth Moss walked out during her acceptance speech at the TCAs. Moss is still affiliated with Scientology.
"No, unfortunately," Remini said sadly. "I wish I was surprised, but that is very -- that is kind of the teachings of Scientology to not watch or listen to anything or anyone who's speaking out against the abuses of it."
She then surprised him by saying that her former friends "literally run away. And it's really sad to watch it."
But even then, she doesn't blame them. "I remember how I felt when I saw people who I was taught and brainwashed into believing were the devil," she said. "It's sad to see them react to me that way when I'm like, I'm me. I don't mean you any harm. I want you to do well in life, I promise you."
After her residency in Las Vegas, Cohen was certain that Lopez would be tapped to host a Super Bowl halftime show, but she said nothing has come her way about that yet.
However, she did seem pretty confident about the possibility, saying, "I feel ilke it will happen when it's supposed to happen. I don't really sweat stuff like that. It would be a great thing. I'm totally open for it and we'll see."
On a related note, a caller asked if she would ever consider following in the footsteps of Cher by hosting her own variety show. Unfortunately, variety shows aren't nearly as popular or successful as they once were, but Lopez definitely seemed intrigued by the idea, which she admitted she'd never really considered.
"It could be fun, I guess," she admitted. "I have a lot of things coming up next year, so maybe not next year. But maybe in the future, who knows?"
Considering the wide variety of jobs she's already held throughout her career -- including dancer, reality show judge, TV star, movie star, producer, director and oh yeah, mega-successful pop star -- there's nothing she couldn't do and do well.