Williams has been absent from her show since December after slurring her words on the air, and then citing pain killers to treat a hairline fracture in her right shoulder as the cause for the unusual behavior.
The celebrity gossip queen shared a statement from her family on Twitter.
"As Wendy Williams Hunter previously shared, she fractured her shoulder and has been on the mend. Over the past few days, Wendy has experienced complications regarding her Graves' disease that will require treatment," the Hunter family wrote. "Wendy will be under the strict supervision of her physicians, and as part of her care, there will be significant time spent in the hospital."
"Despite her strong desire to return, she is taking a necessary, extended break from her show to focus on her personal and physical well-being," the note continued. "Wendy thanks everyone in advance for their well-wishes and for respecting her and the Hunter family's privacy during this time."
Debmar-Mercury, the production company behind her show, added: "For over 10 years, Wendy has been a vital part of the Debmar-Mercury family. We wholeheartedly support Wendy in this decision to take the time she needs and we will welcome her back with open arms the moment she is ready."
According to the company, "The Wendy Williams Show" will air repeat episodes the week of January 21st and will produce original episodes with a variety of hosts starting the week of January 28th.