Rossum was written off the show in the episode "Found" during season 9, but wasn't killed off, so there is the chance of her returning.
Showtime Co-President of Entertainment Gary Levine spoke about the possibility during an interview with Deadline on Monday.
"Too early to say. She would be welcomed with open arms but Emmy doesn't owe us anything," he explained. "She did great for the show as the show did great for her, and it was a very amicable parting. So if she surprises us, it would be lovely."
"Everyone who is in this year is coming back next season, and then you never know in a final season what surprises there may be," he added.
William H. Macy (Frank), Jeremy Allen White (Lip), Kate Miner (Tami), Cameron Monoghan (Ian), Noel Fisher (Mickey), Emma Kenney (Debbie), Ethan Cutkosky (Carl), Christian Isaiah (Liam), Shanola Hampton (V) and Steve Howey (Kev) are set to return.
"Shameless" is the longest running scripted show in Showtime's history. Lead actor Macy has taken home two Screen Actor's Guild Awards, while Joan Cusack won an Emmy for Outstanding Guest Actress in a Comedy Series.
Meanwhile, Rossum is currently filming "Angelyne" about the Los Angeles billboard icon with her husband, Sam Esmail, who created "Mr. Robot." The series is based on a THR article called "The Mystery of L.A. Billboard Diva Angelyne's Real Identity Is Finally Solved" and will stream on NBC's new service Peacock.
"I have always been fascinated by the enigma that is Angelyne," Rossum said in a statement to THR. "At a young age, I can vividly remember staring up at her on a billboard above me and wondering, 'Who is that woman?' Gary Baum's investigative journalism has finally unearthed the true, complex identity of the infamous woman who has fascinated Los Angeles for over 30 years. From the moment I read Gary's recent piece, I knew I had to tell this story. It's a poignant and bizarre tale about the hunger for fame, the sexualization of women and the erasing of past traumas."