"She can do anything she want to do — she Cardi B!" he said, before reminding people to always "please say the B" in a Lil Wayne voice. "Cardi B can do anything man."
Cardi has endorsed Bernie Sanders, but recently expressed interest in a move into politics herself via Twitter.
"I think I want to be a politician. I really love government even tho I don't agree with Goverment," she tweeted earlier this month. (sic)
"Like I was watching War documentaries. No matter how many weapons a country have you need people ! How are you trying to go against a country and possibly start a war when this country lacks patriotism? I barely see people claiming they LOVE being American."
"I will have to explain a lot so I will have to do a video or a live talking about it ...So imma come back to my last two tweets another day," she added. "Imma talk about it another day."
While a straight shot at the White House would be tempting, The Game thinks she should first run for the Senate — but she can skip the City Council stage for sure.
"She should start with New York Senate. Give it four years, let the baby grow up a little bit. Offset, Cardi B in the White House, 2024."
He also mused over what Offset's official title would be, should she prove successful: "First N---a", "First Homie" or "First Husband".
And as for Vice-President, he had no hesitations.
"She should run with Megan Thee Stallion, bro. Megan Thee Stallion, Cardi B, put em on the ticket — I'm voting. On my mama."
Cardi of course wouldn't be the first entertainer to become the Commander in Chief; Ronald Reagan was a Hollywood actor before ascending to the presidency in 1981, while Cardi's fellow rapper Kanye West has threatened a run on a number of occasions.