"Good to see you, how are you doing?" Kelly Ripa asked right when the show began. "Doing well, thank you, I want to thank Mark for filling in yesterday, I appreciate that," said Seacrest.
Ripa's husband Mark Conseulos was Ryan's substitute for on Monday. "It was his pleasure," she told Seacrest.
"He's so good at it. And also [thank you for] all the very kind well wishes from my exhaustion working around the clock," he added. "I got a day off to relax and here we are once again back at it again on 'Live.'"
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The comment comes after one clip from Sunday's "American Idol" finale went viral, where one of Seacrest's eyes appeared larger than the other and his speech was slightly slurred. Viewers speculated he had suffered a stroke, talk which only intensified when he didn't show up on "Live" yesterday.
His publicist eventually issued a statement.
"Ryan did not have any kind of stroke last night. Like many people right now, Ryan is adjusting to the new normal and finding work-home balance, with the added stress of having to put on live shows from home," said his rep, via PEOPLE.
"Between 'Live with Kelly and Ryan,' 'American Idol,' 'On Air with Ryan Seacrest,' and the 'Disney Family Singalong' specials, he has been juggling three-four on-air jobs over the last few weeks and he's in need of rest," the statement continued. "So today he took a well-deserved day off."