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Selena Gomez and Demi Lovato grew up on the set of "Barney" together. After many years of friendship, the two simply grew apart.
Leighton Meester and Blake Lively starred in "Gossip Girl" together. Though once close, rumor has it the pair had a major fallout.
Quite the odd pair. Madonna and Gwyneth Paltrow were BFFs since the '90s. After a major falling out in 2010, the pair no longer hang.
Lauren Conrad and Heidi Montag starred in "The Hills" together. But it ultimately led to the classic BFF breakup with Montag chose her boyfriend (now-husband) over her best friend.
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12 Former Hollywood BFFs

Selena Gomez and Demi Lovato grew up on the set of "Barney" together. After many years of friendship, the two simply grew apart.
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