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Nikki Glaser got candid on The Tonight Show about Ozempic. As a user of the diabetes drug herself, she posted her transformation on Instagram and explained, "Oh, I love it, I love. I’m like, do it, do it." In response to Ozempic critics, Glaser exclaimed, "I feel like there’s this shame. And the shame is only from thin people who want you to stay fat. [...] It’s suddenly all these thin white women who are like, ‘Diabetics need their meds.’ No, I think you’re upset that Kathy Bates has a thigh gap. She’s coming for you."
Amy Schumer says that 3 years after "puking" from trying Wegovy, she's now trying Mounjaro, as well as estrogen and progesterone for her perimenopause symptoms, and she says her experience has been "great." Schumer added, "It’s not covered by insurance unless you have diabetes or like severe obesity, which most of the internet thinks I have. But I’m having a really good experience with it and I wanted to keep it real with you about that."
Hacks' Meg Stalter called out those who "lie" about using Ozempic, saying, "We know if you’re on it because you’re s—ing your pants." She added, "How is that hotter than being fat? That is insane to me. I would rather be 500 lbs. than s—ing all day. That’s so gross ... if you’re taking a drug on purpose just so you lose 10 pounds then, honey, we liked you a little chubbier."
RuPaul's Drag Race Season 9 runner-up Peppermint told Page Six she has lost 100 pounds, after years of struggling to manage her weight, admitting she first got on Ozempic after she was "diagnosed as pre-diabetic a couple of years ago." She added, "I’m very grateful that I’m at a point now where I have access to levels of healthcare that I didn’t have before ... I was really worried that my life was going to change irreversibly once I crossed that threshold [into diabetes]."
Amy Schumer shared on The Howard Stern show that when she tried Ozempic almost three years ago, it caused her to be "bedridden" with nausea. She explained her bad reaction was due to the GDF15 gene, that causes her to be more prone to vomiting. "I lost 30 pounds so quick. I looked great and I couldn't lift my head off the pillow, so what's the point?" she shared, adding, "I tried it and I was vomiting and I'm in bed and my son's like, 'Can you play tag?' I'm like, 'I can't.' I was shriveling."
Josh Gad is using GLP-1 medication for weight loss, calling it a "miracle drug" after losing 40-lbs on a different drug that caused intestinal issues. "I'm figuring out this new one, and it is life-changing," he said on Armchair Expert, adding that he knows he still needs a "healthy relationship" with both food and exercise. "Sometimes I feel like I'm cheating myself by doing this," he added, saying the weight loss made him wonder, "I've always been the funny fat guy. Can I be the funny skinny guy?"
Real Housewives star Cynthia Bailley shared about her negative experience with Ozempic. In an interview, she explained she tried Ozempic because her peers were using it but ended up stopping, explaining it took the fun out of eating: "I didn't enjoy it because when I get my crab cake and my salad and my oysters and my BBQ ribs, I want to enjoy it. I was just literally looking at the food like, 'What is this? What am I supposed to do with this?'" She doesn't extend any hate to people who use Ozempic, but she prefers the support system and more traditional methods of Weight Watchers.
Model Brooks Nader shared that she briefly tried Ozempic during its early popularity, but ended up giving up the weight-loss drug for Dancing With the Stars. In a recent interview with Us Magazine, she said, "It made me really nauseous. I liked it — I am not going to lie — and when I went on Dancing with the Stars, I could not do both." Nader added the drug made her lose "a little bit of the motivation and the strength to work out" and "It was one or the other, and I picked [DWTS]. I put the shot away."
Bonnie Chapman, daughter of the late Beth Chapman and Dog the Bounty Hunter, went from 196 pounds to 126 pounds. However, she used the weight loss drug Tirezepatide after having a negative experience with Ozempic. Of the latter, she said, "I could not eat without feeling nauseous. I could not eat at all, sometimes. My body did not like it." However, with Tirezepatide, she said she was able to overcome nausea within a week, eat smaller portions and feel full, while not actively craving foods that could contribute to weight gain.
Comedian Jim Gaffigan confirmed to PEOPLE he's lost 50 pounds thanks to Mounjaro. This after telling Us Magazine he realized he needed to make a change when he was around "probably 270" pounds. "I was so paranoid that I was going to be nauseous that I kind of put it off, but then it kind of worked," he told the outlet, adding it's "odd" there's a "stigma" around using the drugs. "I'm kind of like a square Midwesterner. I will never look super thin," he added.
Dog the Bounty Hunter's daughter Bonnie Chapman shared an Instagram video, in which she revealed she's "lost 58 pounds in the last 10 months" by using tirzepatide, and praised the weight loss drug. The 25-year-old said it was "impossible" for her to lose weight in the past due to having PCOS. Chapman said tirzepatide made it so she processes food "a little bit slower" so she "stay[s] full longer." She added, "Here I am, 10 months later, I am so in love with the results. I am able to look at myself in the mirror and feel so proud of where I've gotten. I am at my goal weight."
Bunnie XO shared her recent experiences with tirzepatide on her Dumb Blonde podcast, saying that after five days she almost went to the hospital she was so dehydrated from diarrhea. She praised husband Jelly Roll's tour nurse: "She gave me two IV bags and some magnesium, and I felt like a new woman." She says she's lost 4 pounds in 2 weeks, but is taking the meds "to regulate my hormones because I believe I have PCOS." It's been an up-and-down experience, but she told her followers she's "back to pooping normally in case everybody wants to know."
Fat Joe is no longer living up to his stage name, as the rapper told 'US Weekly' all about his journey with Ozempic and losing over 200 pounds. He explained, "Ozempic says you may only have two pieces of your favorite stuff," and while taking the Type 2 diabetes drug, he cut out most carbohydrates and sugars. For example, in the morning, he might only eat the corner of a piece of toast to supplement the rest of his meal. As he went on his journey, he explained a body is like a computer and responds to what one programs/eats, and that as he has gotten older, his physical health has been tied to mental health. Now 200 pounds down, Fat Joe, isn't really "fat," but he assured his fans that the stage name is not going anywhere.
James Corden revealed he tried Ozempic, adding, "and it won’t be surprising to you when you look at me now, that it didn’t really work." He explained trying it "for a bit" made him realize his eating habits had nothing "to do with being hungry," so suppressing his appetite didn't help. "It is not that," he said, "it's something else."
After showing off her recent weight loss -- writing, "FINE BOTH WAYS 😮‍💨😮‍💨😮‍💨" -- Lizzo was met with Ozempic speculation by fans in the comments. In a followup video, she wrote, "When you finally get ozempic allegations after 5 months of weight training and calorie deficit" -- before hitting back at one follower asking if she used weight loss drugs or cocaine by saying, "Whyyy do you follow me?"
After admitting to using Ozempic in early 2024, RHOSLC's Heather Gay later said she "can't win" when it comes to her weight. "I got shamed for being overweight and I got shamed for being on medication," she told E!, adding, ""I'm feel the same. I feel like I liked myself then, I like myself now. It's just Ozempic became available and it worked for me."
Lottie Moss, model and half-sister of Kate Moss, says she started noticing extreme side effects -- like losing color in her face -- after losing 15 pounds in a matter of weeks on Ozempic. At one point, she couldn't keep food or water down and was taken to the hospital, where she suffered a seizure and learned she was taking double the dose for someone her size. "This is a warning to everyone. Please, if you're thinking of taking it, do not take it, it's so not worth it," she said.
After receiving compliments on how "tea" her body looks in a new selfie, Ice Spice said to her followers: "I actually came on here to talk about that real quick. Cuz I was like, bitch, I wish y'all never learned the word Ozempic. That’s one thing I wish. Oh my God! Like what even is Ozempic? What the f–k is that? Genuinely, what is that? Like, you lazy bitches never heard of the gym? It’s called the gym, it’s called eating healthy, it’s called being on tour."
After previously opening up about using Ozempic as a tool to use weight after gaining 18lbs. during her IVF journey, Real Housewives of Dubai star Caroline Stanbury told Page Six she vomited after drinking while on the drug. "If you haven't projectile vomited on Ozempic, you haven’t lived yet," she shared, saying it happened to her at The Abbey bar in West Hollywood. While she has cut back on drinking, it's mainly due to "horrible hangovers" and not because of her experience at The Abbey.
After telling TooFab her "body didn't take it well," Macy Gray speaks more about her Ozempic experience on The Surreal Life -- admitting she's "kind of a vain person" and started taking it before the show because she "didn't want to be super fat on TV." Describing her side effects, she said, "My stomach hurts. I've just been really constipated. I was up all night."
Bella Thorne shared she hasn't "been feeling good about my body for a while," saying weight loss drugs are "setting all these crazy beauty standards that nobody can keep up with unless you're on Ozempic." In a bikini video she added, "I'm finally feeling good about myself ... so Ozempic, you can," she continued, before flipping off the camera.
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Stars Who Have Spoken Out On Weight Loss Drug Trend In Hollywood

After receiving compliments on how "tea" her body looks in a new selfie, Ice Spice said to her followers: "I actually came on here to talk about that real quick. Cuz I was like, bitch, I wish y'all never learned the wor... READ MORE
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