Jennifer Aniston and Justin Theroux Separate

The two announced their separation on Thursday in a joint statement:

"In an effort to reduce any further speculation, we have decided to announce our separation. This decision was mutual and lovingly made at the end of last year. We are two best friends who have decided to part ways as a couple, but look forward to continuing our cherished friendship. Normally we would do this privately, but given that the gossip industry cannot resist an opportunity to speculate and invent, we wanted to convey the truth directly. Whatever else is printed about us that is not directly from us, is someone else's fictional narrative. Above all, we are determined to maintain the deep respect and love that we have for one another."

They tied the knot on August 5, 2015 after four years of dating. They share no children.

Aniston recently celebrated her 49th birthday and attended Ellen DeGeneres' birthday party without Theroux by her side, now we know why. She was also in attendance at Amy Schumer's surprise wedding this week.

The actress was previously married from 2000 to 2005 to Brad Pitt, who split from Angelina Jolie in 2016.