Set in New York City during "the deadliest year," the new season stars Joe Mantello, Billie Lourd, Zachary Quinto, Russell Tovey, Leslie Grossman, Charlie Carver, Sandra Bernhard, Isaac Powell, Denis O'Hare and Patti LuPone. The premiere will include the first two episodes of the 10-episode season, followed by two episodes each Wednesday for four subsequent weeks.