The two women discuss the Weinstein effect in conjunction with Vogue's 125th anniversary.
While the powerful duo breezed right past Streep's flawless portrayal of Miranda Priestly in the 2006 film during their conversation for the magazine's December issue, they did address the sexual harassment and assault controversy currently rocking Hollywood.
"Harvey Weinstein. That's all we talk about. It's horrible," Streep said when asked what her family talks about at the dinner table. "We want them to be free. We want them to be proud. We want them to be female. But you put them in danger by not informing them about the male gaze and how it works on young girls."
Meryl is mom to three daughters; Mamie Gummer, 34, Grace Gummer, 31, and Louisa Gummer, 26.
"This moment is absolutely thrilling. This is a door that will not be closed, we've got our foot in there now," she said of the Weinstein effect. "It'll be very difficult to conduct their lives the way they have in the past ... we're civilized people and we learn form our mistakes."
The two also talked about Streep's new role in Steven Spielberg's film "The Post," a movie that explores how America's first female publisher, Katharine Graham, broke the Watergate scandal. The late Graham happened to be a close friend and mentor of Wintour's. Streep then explained how one of the biggest themes of the movie is still relevant today.
"One of the themes of the film is how difficult it is to stand up," Streep said. "And so that sort of speaks to our moment where the truth is so amorphous and difficult to nail down... It's hard to risk a great deal to tell the truth."
Wintour then asked Streep if Graham was the most challenging role she's played. Just when it seemed like Meryl was about to answer with character based on Anna, she was cut off. "We're not going there, Meryl!" Wintour said with a laugh.
"No, that wasn't anyway," Streep replied, "That was fun!"