"I couldn't see myself doing a sitcom or a television show kind of thing," he said during the nearly two-hour long interview.
"They pursued me for 'The Big Bang Theory' and I said nah," he continued. "The way the pitch was it was like, these two astrophysicist nerds and a pretty girl lives with them, yoinks! That was the pitch."
"They were like, we're going to get some real physicists to do the math and I was like no, I'm cool, thanks," Culkin added. "They came back at me again, but again, flattered, no."
"Them came back to me again and even my manager was twisting my arm," he continued.
While he knows he'd "have hundreds of millions of dollars now" if he had taken the role, he added that he'd probably "be bashing my head against the wall" off set.
The 37-year-old said, in general, he's not into acting anymore.
"I don't pursue it in any way, I don't have agents," he explained. "I don't like the pursuit of it. I don't like being on the circuit kind of thing. I write a lot, I paint a lot."
He also has his own comedy website and says he's "pretty put together" these days.
"I have a good life now, I have a special lady friend, we have a dog and a cat," he said. "I'm gonna make some babies, this one's a good one, I'm probably going to put some babies in her in a bit. We've definitely been practicing."
"She's Asian, so I'm gonna have tiny little Asian babies, it's going to be adorable," he said. "A bunch of Sean Lennons running around the house, that's what I'm looking for."