He has a few movies in the pipeline as well, including a "Tarzan" adaptation, and is now happily dating "Step Up 3D" star Sharni Vinson.
Nikki Reed -- Rosalie Hale
For Nikki, most of her big changes have happened off-screen.
Known for roles in "Seventeen" and on "The O.C." before "Twilight," Reed been making more headlines lately thanks to her personal life.
Nikki met former "American Idol" contestant Paul McDonald at the "Red Riding Hood" premiere and began dating in March 2011. They were engaged three months later and tied the knot in October 2011.
The two are now working on music together and just recorded a five-song EP called "The Best Part."
Reed also has a few projects in the pipeline, including "Pawn" with Forest Whitaker and Michael Chiklis.
Jackson Rathbone -- Jasper Hale
Before playing Jasper in the "Twilight" flicks, Rathbone was really only known for his role on the short-lived ABC Family show "Beautiful People."
Jackson's side projects while doing "Twilight" included the critically panned "The Last Airbender" and an episode of "Criminal Minds."
"Twilight's" success helped increase interest in Jackson's band, 100 Monkeys, which went on tour from 2010-2011.
Offscreen, Rathbone and his girlfriend Sheili Hafsai recently welcomed son Monroe into the world -- and his movie-wife Nikki Reed is the baby's godmother!
Elizabeth Reaser -- Esme Cullen
Elizabeth Reaser's role as Esme Cullen hasn't been much of a game-changer for her.
She continued to guest star on "Grey's Anatomy" -- a gig she started before the first "Twilight" movie -- and appeared on "The Good Wife" in a multi-episode arc. She also had a bit role in the Charlize Theron flick "Young Adult."
Peter Facinelli -- Carlisle Cullen
Pete's been in the business for a while, but he's seen some big changes in his life since joining the "Twilight" family.
Before becoming Dr. Carlisle Cullen, Peter was best known as jock Mike Dexter in "Can't Hardly Wait" and for stints on "Six Feet Under" and "Damages."
After the first movie came out though, Facinelli was cast opposite Edie Falco on Showtime's "Nurse Jackie."
Recently, it's his personal life that's been making headlines after he filed for divorce from wife of 11 years, Jennie Garth. The former couple has three kids together.