But out of all of the fun throughout the show, it was De Rossi who truly made Ellen's day with the most thoughtful gift someone could give a multi-millionaire, so let's start there.
Ellen Got Her Own Wildlife Foundation
"It's your 60th birthday and this gift had to be really special and it had to represent who you are and what you really care about," Ellen's wife said. "Not just now, but what you've always cared about. What you were influenced by and what has made you the amazing person that you are today. So, I combined that and questions when we first met like who's your idol? And what would you do if you weren't a talk show host?"
"So, I combined that with the fact that -- literally guys -- for like the last two years, Ellen has said to me, 'I feel like I'm not doing enough.' Every day, almost. So, I put all that together and I got you this gift. So let's see it -- happy birthday."
De Rossi then played a video of her narrating a story about Ellen's hero Dian Fossey.
"So for your birthday, Ellen, I am bringing you and your hero, Dian, together by building The Ellen DeGeneres Campus of the Dian Fossey Gorilla Fund," she said. "Ellen, you will carry on Dian's legacy by giving them a permanent home in Rwanda. Now, you will join Dian as a protector and champion of these amazing animals, the mountain gorillas. Happy birthday."
But De Rossi had one more surprise up her sleeve. She also set up a foundation called The Ellen DeGeneres Wildlife Fund so the busy entertainer can support any animal cause she wants.
While Ellen was playing a game of "Show Did/Show Didn't," in which she was challenged to recall previous interactions with celebrity guests as fact or fiction, the ABC late-night host surprised her by turning a "Show Didn't" into a "Show Did" on the spot.
"Jimmy Kimmel appeared on the show dressed as an Olympic figure skater," she read off a card. "That sounds like he would for sure do that."
And he did, emerging from backstage in full costume, even performing a mock skating routine for everyone's entertainment before joining Ellen for a quick chat.