Kanye also admitted he was "delusional" to believe he compared to Jay-Z as a rapper — to the point he denied his frenemy a chance at recording "Jesus Walks".
Kanye West's next fight is against the US mental health care system.
The rapper vowed to change how mentally ill people are treated after recounting some of his own harrowing experiences to David Letterman on his Netflix show, "My Next Guest Needs No Introduction".
Describing one of his "hyper-paranoid" episodes, he recalled: "You feel everyone wants to kill you, you pretty much don't trust everyone, and they have this moment where they handcuff you, they drug you, they put you on the bed, and they separate you from everyone you know."
"That's something that I'm so happy I experienced myself so I can start by changing that moment. When you are in that state, you have to have someone you trust. It is cruel and primitive to do that."
He said that failing to take medication could induce these states and cause him to "ramp-up".
"When you ramp up, it expresses your personality more. You can become almost more adolescent in your expression," he explained. "This is my specific experience that I've had over the past two years, because I've only been diagnosed for two years now."
"When you're in this state, you're hyper-paranoid about everything. Everyone — this is my experience, other people have different experiences everyone now is an actor. Everything's a conspiracy. You feel the government is putting chips in your head. You feel you're being recorded. You feel all these things."
The rapper claimed mental health problems were just like any other health problems — with added stigma.
"This is a sprained brain, like having a sprained ankle," he insisted. "And if someone has a sprained ankle, you're not gonna push on him more. With us, once our brain gets to a point of spraining, people do everything to make it worse. They do everything possible. They got us to that point, and then they do everything to make it worse."
Kanye revealed he has been off medication for eight months, and feared it would affect his creative process.
"That's just the reality. You know, if you guys want these crazy ideas, these crazy stages, this crazy music, and this crazy way of thinking, there's a chance it might come from a crazy person," he laughed.
During the interview, which airs on Netflix along with the rest of season 2 on Friday, Kanye admitted he was "delusional" to believe he compared to Jay-Z as a rapper — to the point he denied his frenemy a chance at recording "Jesus Walks".
"I had the confidence, this delusional confidence, to think I could rap as good as Jay-Z — even to the point of not playing him beats and saving them for myself. People think I'm crazy now, they thought I was crazy then. 'You ain't finna play "Jesus Walks" for JAY-Z?' I was like, "Nah, I'll stash this one"."
Kanye also admitted he wasn't allowed to mention Drake by name... without mentioning his name.
"An artist which I will not mention because I'm not allowed to mention him or any of his family members," is how he described him. When Letterman called the description "fairly provocative", Kanye explained, "Well, we had a little beef last year," before quoting a favorite line from Drake's "Crew Love."