"I don’t want to act like Donald Trump and just spout out accusations without having any proof whatsoever, so let's take a look at the facts," she said in the "Bright Side" segment (above), inspired by a New Republic article.
"Symptoms include patchy hair loss, squinting or vision problems and even paranoid thoughts, like the mainstream media’s out to get you or all Mexicans are rapists or a black guy wiretapped your deluxe apartment in the sky," she joked before showing a montage of Trump's behavior that in theory could be the result of the STD.
"Now I’m not a doctor, so I can’t claim Donald Trump has syphilis, because of laws," she said. "But as the saying goes, if it walks like a duck and talks like a duck, it probably f--ked some questionable models in the '80s."
If this clip is any indication of what Handler's got in store for viewers this season, it's safe to say she'll join the late-night-makes-fun-of-Trump party with ease.
New episodes of "Chelsea" premiere on Netflix every Friday.