Saying Kim Kardashian married the "King of All Blacks," Williams criticizes Kanye for ever appearing on her reality show.
Since coming back to the social media site on April 15, he's promoted new music, while also making headlines for showing support to right-wing commentator Candace Owens and Donald Trump fan/"Dilbert" creator Scott Adams.
"Kanye West has really lost his mind," said Williams at the top of Tuesday's show. "And I don't mean that in a humorous way. We've seen him on a slippery slope for a long time. This is really sad, you all."
"In the last week, he's tweeted 112 times. Plenty of people do that, the problem with his is that they're rants, his thoughts about god, his thoughts about slavery is a mentality, he talked about supporting right winger Trump and the Trump supporters. He's talking about deprogramming, he wants to deprogram people," she continued. "It's just a slippery, slippery slope."
She then said West hasn't "hasn't been the same" since his hospitalization in 2016, when he was treated for a mental breakdown. Williams added, "He hasn't been the same since he married Kim [Kardashian]."
"All I'm saying is, whatever happened to the thought provoking Kanye we knew who was slightly nutty ... nutty is good, we're all a little nutty ... but when he got with that family, Number 1, he should have stayed like the mack in the back, he should not have participated in the reality show," she rambled on. Williams also said Kardashian's marriage to West -- who she called "King of All Blacks" -- was a "come up" from her past relationships.
"This is not an attractive way for people to support his music. I don't want to hear rants," she added, going back to his tweets. "I'm not laughing. There are very few people in the music game that can disappear like he has for 2 years, but still manage to remain relevant."
Wendy's final words for West: "He needs to take another two years. Put your message in your music, don't talk."