"She is crackerjack on the money on women's issues and I call her the ambassador of empathy," he said. "And out country could use a dose of empathy right now. She's been on the air for 35 years with all kinds of social outreach, building bridges between different ideologies and different points of view."
Although Winfrey doesn't have any political experience, he believes she has the will power to rise to the occasion.
"I think she'll learn on the job the same way Bill Clinton learned -- a former governor of Arkansas -- or Barack Obama, a junior senator, learned on the job," he said. "I'd much rather go for someone like Oprah Winfrey than a career politician."
Speculation of the former daytime talk show host running against Donald Trump in the next election began on Twitter after her rousing speech at the Golden Globes Sunday night.
Winfrey was awarded the Cecil B. DeMille award, and took advantage of her platform to talk about social progress, as well as the often difficult and ugly trail it takes toward reality.
Host Seth Meyers was on board the Winfrey presidency train before her speech even began, telling a joke during his opening monologue about a Winfrey-Hanks ticket. By the end of her speech, the rest of America was ready to head to the polls, if their Twitter response was any indication.