Clooney appeared on the show from 1988 to 1991 as Booker Brooks, Roseanne's co-worker and love interest of Jackie.
Roseanne Barr appeared on The Howard Stern Show on Tuesday, where she was asked by the host if any of the show's original cast members gave her a hard time about returning. While the core players -- including John Goodman, Sara Gilbert, Laurie Metcalf, Johnny Galecki, Michael Fishman and both Beckys, Lecy Goranson and Sarah Chalke -- said yes, Clooney was a definite no-go.
"Well, George Clooney didn't want to come on, so that was a bummer," Barr admitted. "I thought, well, he lives in Italy."
"He's said some really silly things about me, but I still love him," she added, without going into specifics.
Stern then asked if a story he'd heard about George from back in the day was true -- that the actor had smashed a chocolate candy bar the network sent after the show reached #1 in the ratings. She confirmed the tale, saying he was ticked off because he knew what kinds of gifts other actors received for hitting similar milestones.
"[Clooney] goes, 'Let's go out, and I'll throw it … and you hit it with a bat and then we'll send the picture to the president of the network," Barr exaplained. "He goes, 'they f-cking gave whatshisface a Rolls Royce on this network!"
"That caused a lot of problems for me," she added. "I should not have sent that picture. But it's so funny."
She also said Clooney would stoke her fear of being replaced on the show but putting the name "Sandy Duncan" on her dressing room door, a reference to the actress who took over Valerie Harper's spot on "The Hogan Family."
Clooney wasn't the only famous face to appear on the show during it's original run -- click through the gallery below!