"I feel sad for you," Khloe writes after one fan takes aim at her relationship with Scott.
Earlier this week, Khloe posted a lengthy birthday tribute to Kourtney Kardashian's baby daddy on Instagram, explaining how "thankful" she was to have him as part of their wild family.
But one of her followers clearly hit a nerve by saying they "refuse to believe they've never shagged."
In a fiery response, Khloe said the comment "makes me feel sad for you."
"I feel sad for you because apparently you don't have relationships in your life that can be completely platonic," Kardashian continued. "You don't have relationships where someone genuinely loves and cares about you without wanting anything else besides a friendship."
"Scott and I are family. Our family (Scott included) have experienced a ton together and we love each other fiercely because of it all," she went on. "I really pray that you have healthy loving relationships in your life. Where it's an equal give-and-take relationship. I hope you have some relationships in your life where 'shagging' is NOT involved."
She ended her message with this mic drop: "And I hope you stop saying the word shag lol"
Check out Khloe's initial post below:
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Happy birthday to my brother @letthelordbewithyou !!! I am so thankful to have such an incredible addition such as you to our family! We have come such a long way, you and I! I am so thankful for the person that you have grown into. I am thankful for every highs and lows because we have been through it all and we are closer than ever. I am proud to say that you are my brother and also one of my best friends! Have the best birthday Lord!! FOREVER the Lord and the Lady