During the interview Stern asked the former first lady to raise her right hand and swear that she's never "had a lesbian affair."
"Never, never, never!" Clinton quickly replied. "Never even been tempted, thank you very much." Then she added with a laugh, "Contrary to what you may hear, I actually like men."
She also said that she rarely had trouble finding a suitor prior to marrying Bill Clinton.
"There was somebody before [Bill], not to marry, but I loved him," she explained on the show, adding that she "dated a lot of different people."
Clinton and Stern covered a variety of topics during the interview including her feelings on the wavering loyalties of Senator Lindsay Graham - "It's like he had his brain snatched" - and a rock 'n' roll legend she calls friend - Mick Jagger.
Stern finally asked Clinton if she ever thought she'd leave the public eye and go "full seclusion." She coyly replied that it "would only delight my adversaries, so I would never do that."
The former Secretary of State was on "The Howard Stern Show" to promote her new literary foray "The Book of Gutsy Women," which she wrote with her daughter Chelsea Clinton.