Chen has been co-host on the show since its debut in 2010.
Announcing the news in a pre-taped video from the set of "Big Brother," Chen said, "I have been at 'The Talk' since the day it started 9 years ago and the cast, crew and staff have become family to me over the years. But right now, I need to spend more time at home with my husband and young son, so I've decided to leave 'The Talk.' I want to thank everyone at the show for the wonderful years together, I will always, always cherish the memories we shared."
"Most important, I want to thank you, the viewers, for allowing me into your home everyday," she continued. "It was a privilege that I will forever be grateful for."
Farewell ❤️❤️ pic.twitter.com/1eOCpelor1— Julie Chen (@JulieChen) September 18, 2018
Choking back tears, she continued, "For everyone behind the scenes, I send you my love, I will miss you all very, very much."
She then addressed her co-hosts one by one. "To Eve, you're the newest one at the table but I feel like I've known you forever," she said. "You are even more beautiful inside than you are on the outside, if that's even possible because you know I think you are flawless."
"Sheryl, thank you for being the perfect go-to partner for the last 7 years. I open, you close, and you always bring down the house," she said of Sheryl Underwood. "We called ourselves the bookends, remember, and we always laughed when we said it to each other. You wit and timing and humor and compassion and intelligence is simply unparalleled, you are incredible."
"Carrie Ann, I don't know, but in my opinion, you look awful good in that chair my Asian sister," she said to guest co-host Carrie Ann Inaba.
Lastly, she sent a message to Sharon Osbourne and Sara Gilbert. "We've been together since Day 1 at 'The Talk.' I've spent every day with you both, I'll always treasure our friendship, the great parenting advice from both of you, the memories and laughs and all the private jokes that the three of us have shared. We are the original three musketeers. I love you all and I know this show and the sisterhood it stands for will live on for many many many more years to come. You ladies got this and I could not be more proud to call you my friends. I love you."
She's been on the panel since the show's debut in 2010.
In response, Gilbert said, "First of all, thank you so much Julie for the kind words. I created this show as a place for friends to come together and I know I speak for all the hosts when I say we thank you for 8 years of dear friendship and for all you did to contribute to the success of the show. We love you Julie."
The announcement from Chen comes after her husband, Les Moonves, was accused of sexual harassment and assault by multiple women. Moonves resigned from CBS after the allegations were made.
The fallout for Moonves began when journalist Ronan Farrow wrote an article in The New Yorker back in July 2018. In the story, six women claimed that Moonves had either harassed, intimidated, or abused them while at CBS. The network subsequently investigated the executive. Then, earlier this month, six more women came out to accuse Moonves.
When the first allegations came to light, Chen tweeted: "Leslie is a good man and a loving father, devoted husband and inspiring corporate leader. He has always been a kind, decent and moral human being. I fully support my husband and stand behind him and his statement."
This was the first time Chen used her full married name in the history of the show -- she's been playing host to "Big Brother" for 18 years.
She and Moonves have been married since 2004.