"They're just chasing Meghan Markle everywhere, she's been pursued and vilified," Clooney told reporters at a press panel, according to Australia's Who magazine.
"She's a woman who is seven months pregnant and she has been pursued and vilified and chased in the same way that Diana was," he continued. "It's history repeating itself."
"We've seen how that ends," Clooney added in reference to Princess Diana's fatal car crash in 1997, which occurred when the vehicle was being chased by paparazzi. "I can't tell you how frustrating that is, just seeing them broadcast a letter from a daughter to a father, she's getting a raw deal there and I think it's irresponsible and I'm surprised by that."
Clooney, 57, who along with his wife Amal, 41, attended Markle's wedding to Prince Harry last May. The royal couple are expecting a child due sometime this spring. But could Clooney, who is father to twins Ella and Alexander, possibly be involved with the royal baby in a big way?
"Oh yes, I'll be godfather of the royals apparently," Clooney told Who, before clarifying he was joking, "No!"
"I'm a father of twins," the actor added. "I have enough shit to deal with -- literally!" Amal, who has been married to Clooney since 2014, gave birth to the twins back in June 2017.