Huston claims Oprah shut her out after beating her for an Oscar win.
While she defended Jeffrey Tambor and Woody Allen -- who have been accused of sexual misconduct -- in the interview, Huston called out the behavior of stars including Oprah Winfrey, Bill Murray and Eddie Murphy.
According to Huston, Oprah has a problem with her after she won the Oscar for "Prizzi's Honor" the same year Winfrey was nominated for "The Color Purple." When asked about the "repercussions" of beating O, Huston said, "She never had me on her show, ever. She won't talk to me."
"The only encounter I've had with Oprah was when I was at a party for the Academy Awards, a private residence," she continued. "I was talking to Clint Eastwood, and she literally came between us with her back to me. So all of the sudden I was confronted with the back of Oprah's head."
When asked if she specifically thought Winfrey acted like that because Huston beat her, she replied, "Well, nobody else would dislike me so much as to literally, physically come in between the person I was talking with that way. But I admire Oprah. God knows, she's made some big steps."
Huston also addressed reports Eddie Murphy can be a bit of a diva, as she was asked whether it's true he asks everyone to arrive on set before him.
"You'd be waiting for over 15 minutes in a California summer, so you're not appetizing by the time you get on-camera," she explained. "Maybe he didn't recognize that factor. So I requested to at least know when he was traveling to set. His reply, through the grapevine, was 'Ladies first.' Frankly, a lot of male movie stars behave in an offhand manner, like they're just more important than you are."
Another actor she claims gave her grief: Billy Murray.
"He was a shit to me on 'Life Aquatic,'" Huston claimed. "The first week I was there, we were all in this little hotel, and he invited the entire cast to go and have dinner, except me. And everyone came down for dinner, a little dog-faced about my not being invited, and they were all like, 'Oh, you know, we don't really want to go.' That was worse than anything."
She said she later called him out on his behavior and he's been "a little nicer" to her since, adding that he was one of the few who attended husband Robert Graham's funeral.
Huston, who stars in "John Wick: Chapter 3 - Parabellum," also couldn't resist throwing a little shade at another movie opening this month during the interview, after she was asked about the type of films she's drawn to at this stage in her career.
"I'm looking for movies that impress me in some way, that aren't apologetically humble or humiliating like, 'Band of cheerleaders gets back together for one last hurrah,' you know. An old-lady cheerleader movie,'" she said. "I don't like that kind of thing. If I'm going to be an old lady — and I’m sort of touching old lady these days — at least I want to be a special old lady. I don't want to be relegated to some has-been making a comeback. I hate comebacks."
Diane Keaton's "Poms" opens May 10, "John Wick" hits theaters May 17.
Read Huston's full, lengthy and incredibly candid interview over at Vulture.