Philbin was best known for hosting "Live! With Regis and Kathie Lee," "Live! With Regis and Kelly," and "Who Wants to Be a Millionaire?"
Celebrities shared their heartfelt tributes to the legend online, as Hoda Kotb posted a picture of Philbin with her former "Today" co-host Kathie Lee Gifford and the caption, "Heartbroken. We will miss you Regis."
Gifford paid tribute as well, writing, "REGIS. There will never be another."
Jimmy Kimmel called Philbin "a great broadcaster, a good friend and a tremendous amount of fun. He leaves behind a beautiful family and a TV legacy that will likely go unmatched."
"Real Housewives of Beverly Hills" star Lisa Rinna tweeted, "The end of an era. A great friend and mentor. I will never forget your generosity of spirit sweet Regis. You changed my life and I will never forget the lessons you taught me. You showed me how to fly. May you Rest In Peace with the angels."
Actress and comedian Rosie O'Donnell shared an interview clip from when Philbin appeared on her talk show back in 1997. "He was a lovely man #RIPRegisPhilbin," she wrote.
"We are beyond saddened to learn about the loss of Regis Philbin," the statement read. "He was the ultimate class act, bringing his laughter and joy into our homes everyday on Live for more than 23 years. We were beyond lucky to have him as a mentor in our careers and aspire everyday to fill his shoes on the show. We send our deepest love and condolences to his family and hope they can find some comfort in knowing he left the world a better place. - Kelly and Ryan."
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This one hurts. A staple in our household growing up, his joy was infectious and his hosting skills among the greatest I’ve ever seen. Whether on “Live” or leading “Who Wants to be a Millionaire” he was always captivating & hilarious. #RIPRegishttps://t.co/PoajN1yb3W
Regis was a great broadcaster, a good friend and a tremendous amount of fun. He leaves behind a beautiful family and a TV legacy that will likely go unmatched. Regis, I hope our friend Rickles met you at the pearly gates with open arms and a slew of the insults you loved so much
I truly believed that #RegisPhilbin would be a presence with us forever. He was a fun, funny, charming man. On the occasions I got to be with him, he was always a bright light, endlessly interesting and interested in everyone. Sympathy to his loved ones. #ripregisphilbin
We are heartbroken to hear that a long time colleague & friend, #regisphilbin passed away at the age of 88. Regis graced us with warmth, humor & a self-deprecating wit, always bringing happiness to us all. Our hearts go out to Joy and to his family. Rest In Peace, Regis.
Another highlight of my career was co-hosting with Regis on Live It was a once in a lifetime moment to sit beside the king of improv tv. He was funny and gracious and warm. Love to Joy and his family. #RIPREGISpic.twitter.com/gDrdH4o2aY