She continued, "In this latest series, the characters are facing many of the same challenges that exist in reality right now. I believe the Duffer Brothers have touched people's hearts in a special way, at a time that's incredibly difficult for everyone, especially younger people."
"Running Up That Hill" plays a vital role in this season's plot line with Sadie Sink's character Max using the track to literally save her own life.
"By featuring 'Running Up That Hill' in such a positive light - as a talisman for Max (one of the main female characters) - the song has been brought into the emotional arena of her story," Bush stated. "Fear, conflict and the power of love are all around her and her friends."
"I salute the Duffer Brothers for their courage - taking this new series into a much more adult and darker place. I want to thank them so much for bringing the song into so many people’s lives," she added. "I'm overwhelmed by the scale of affection and support the song is receiving and it's all happening really fast, as if it's being driven along by a kind of elemental force."
After being featured in "Stranger Things," the '80s track has shot up to No.1 in the U.K. and Australia for the first time as well as entered the U.S. Top 5, per Billboard.
"I have to admit I feel really moved by it all," she concluded. "Thank you so very much for making the song a No. 1 in such an unexpected way."